INS, Mouse, Clone: ISL-8J, Abnova™

Catalog No.	Quantity
89-110-461	100 μg

Catalog No. 89-110-461 Supplier Abnova Corporation Supplier No. MAB1502

Description

Mouse monoclonal antibody raised against native INS.

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq]

Specifications

• Antigen: INS
• Applications: Immunohistochemistry (PFA fixed)
• Classification: Monoclonal
• Clone: K36AC10
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against native INS.
• Dilution: Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.4-1 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: Lyophilized from 1.2% sodium acetate (2mg BSA, 0.01mg sodium azide)
• Gene: INS
• Gene Alias: ILPR/IRDN
• Gene Symbols: INS
• Host Species: Mouse
• Immunogen: Native purified human INS.
• Purification Method: Affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3630
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at -20°C on dry atmosphere. After reconstitution with 1mL of 1.2% sodium acetate or neutral PBS to a concentration of 100μg/mL store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Form: Lyophilized
• Isotype: IgG1