Mouse anti-Integrin beta 2/CD18, Clone: 68-5A5, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP2449630.2MG

Catalog No. NBP24496302

Description

Ensure accurate, reproducible results in Flow Cytometry, Immunofluorescence

Integrin beta 2/CD18 Monoclonal antibody specifically detects Integrin beta 2/CD18 in Human samples. It is validated for Flow Cytometry, SDS-Page, Immunofluorescence.

Specifications

• Antigen: Integrin beta 2/CD18
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Dilution: Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml
• Gene Alias: 959 beta subunit precursor)10, CD18 antigen, CD18beta 2, cell surface adhesion glycoprotein (LFA-1, CR3, integrin beta-2, integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1;macrophage antigen 1 (mac-1) beta subunit), integrin, beta 2 (complement component 3 receptor 3 and 4 subunit), LAD, LCAMB, leukocyte cell adhesion molecule CD18, leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C, MF17, MFI7, P150
• Host Species: Mouse
• Molecular Weight of Antigen: 95 kDa
• Quantity: 0.2 mg
• Research Discipline: Apoptosis, Cytokine Research, Immunology
• Gene ID (Entrez): 3689
• Target Species: Human
• Form: Purified

• Applications: Flow Cytometry, SDS-Page, Immunofluorescence
• Clone: 68-5A5
• Conjugate: Unconjugated
• Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
• Gene Symbols: ITGB2
• Immunogen: Stimulated human leukocytes
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: It recognizes a transmembrane glycoprotein of 95kDa, identified as CD18 or integrin -2 (Workshop III). It complexes non-covalently with either L, M, or X integrin (CD11a, b, or c) to form the heterodimers, LFA-1, Mac-1, and p150,95, respectively. LFA-1 is the receptor for three members of the Ig supergene family of proteins, ICAM-1 (CD54), ICAM-2 (CD102), and Mac-1 and p150,95 bind to ICAM-1, fibrinogen, and iC3b. ICAM-3 (CD50). CD18/CD11 heterodimeric molecules are involved with cell/cell and cell/extracellular adhesion in immune and inflammatory responses. This MAb blocks these cellular interactions.
• Content And Storage: Store at 4C.
• Isotype: IgG2a κ

For Research Use Only