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Description
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq
Specifications
Specifications
| Antigen | ITGA2B |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Clone | 96.2C1 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against native ITGA2B. |
| Dilution | The optimal working dilution should be determined by the end user. |
| Formulation | In 50mM sodium phosphate buffer, 100mM potassium chloride, 150mM NaCl, pH 7.5 (0.5mg/mL gentamicin sulfate) |
| Gene | ITGA2B |
| Gene Alias | CD41/CD41B/GP2B/GPIIb/GTA/HPA3 |
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