ITGA2B, Mouse, Clone: P2, Abnova™

Catalog No.	Quantity
89-111-713	200 μg

Catalog No. 89-111-713 Supplier Abnova Corporation Supplier No. MAB4143

Description

Mouse monoclonal antibody raised against native ITGA2B.

ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq

Specifications

• Antigen: ITGA2B
• Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (Frozen)
• Classification: Monoclonal
• Clone: P2
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against native ITGA2B.
• Dilution: Flow Cytometry (2ug/5x10⁶ platelets/test) Immunohistochemistry (Frozen sections) (1:50-1:100) The optimal working dilution should be determined by the end user.
• Formulation: Lyophilized from PBS (1mg/mL BSA)
• Gene: ITGA2B
• Gene Alias: CD41/CD41B/GP2B/GPIIb/GTA/HPA3
• Gene Symbols: ITGA2B
• Host Species: Mouse
• Immunogen: Native purified ITGA2B from human platelets.
• Quantity: 200 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3674
• Test Specificity: Reacts with gpIIb in the intact complex with gpIIIa, but not with IIb or IIIa, separately. Inhibits platelet aggregation induced by thrombin, collagen and ADP. The molecular weight of the recognized complex is 135KDa/95KDa.
• Target Species: Human
• Content And Storage: Store at 4°C on dry atmosphere. After reconstitution with deionized water store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Form: Lyophilized
• Isotype: IgG1 κ