ITGAL, Mouse, Clone: MEM-25, Abnova™
Mouse monoclonal antibody raised against native ITGAL.
Manufacturer: Abnova Corporation MAB0876
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
|Mouse monoclonal antibody raised against native ITGAL.|
|In PBS, pH 7.4 (0.09% sodium azide)|
|Native purified ITGAL from leukocytes of a patient suffering from a LGL-type leukemia.|
|Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.
|This antibody reacts with CD11a (alpha-subunit of human LFA-1), a 170-180 KDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils.|
|Flow Cytometry, Immunoprecipitation|
|The optimal working dilution should be determined by the end user.|