ITGAL, Mouse, PE, Clone: MEM-25, Abnova™

Catalog No.	Quantity
89-111-906	100 Reactions

Catalog No. 89-111-906 Supplier Abnova Corporation Supplier No. MAB4570

Description

Mouse monoclonal antibody raised against native ITGAL.

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Specifications

• Antigen: ITGAL
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: MEM-25
• Conjugate: PE
• Description: Mouse monoclonal antibody raised against native ITGAL.
• Dilution: Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 10⁶ cells in a suspension) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.2% BSA, 0.09% sodium azide)
• Gene: ITGAL
• Gene Alias: CD11A/LFA-1/LFA1A
• Gene Symbols: ITGAL
• Host Species: Mouse
• Immunogen: Native purified ITGAL from leukocytes of patient suffering from LGL-type leukaemia.
• Quantity: 100 Reactions
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3683
• Test Specificity: This antibody reacts with CD11a (alpha-subunit of human LFA-1), a 170-180 KDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils.
• Target Species: Human
• Content And Storage: Store in the dark at 4°C. Do not freeze.
  Avoid prolonged exposure to light.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1