ITGB1, Mouse, Biotin, Clone: MEM-174, Abnova™

Catalog No.	Quantity
89-111-887	100 μg

Catalog No. 89-111-887 Supplier Abnova Corporation Supplier No. MAB4546

Description

Mouse monoclonal antibody raised against native ITGAM.

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Specifications

• Antigen: ITGB1
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: MEM-174
• Conjugate: Biotin
• Description: Mouse monoclonal antibody raised against native ITGAM.
• Dilution: Flow Cytometry (1:400) The optimal working dilution should be determined by the end user.
• Formulation: In PBS, pH 7.2 (0.09% sodium azide)
• Gene: ITGAM
• Gene Alias: CD11B/CR3A/MAC-1/MAC1A/MGC117044/MO1A/SLEB6
• Gene Symbols: ITGAM
• Host Species: Mouse
• Immunogen: Native purified ITGAM from human granulocytes.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3684
• Test Specificity: This antibody recognizes CD11b antigen (Mac-1 alpha), a 165-170 KDa type I transmembrane protein mainly expressed on monocytes, granulocytes and NK-cells. The CD11b mediates neutrophil and monocyte interactions with stimulated endothelium.
• Target Species: Human
• Content And Storage: Store at 4°C. Do not freeze.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG2a