ITGAM, Mouse, FITC, Clone: MEM-174, Abnova™

Mouse monoclonal antibody raised against native ITGAM.

Supplier:  Abnova Corporation MAB4549

Catalog No. 89-111-890

Description

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Specifications

• Antigen: ITGAM
• Classification: Monoclonal
• Conjugate: FITC
• Dilution: Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 10⁶ cells in a suspension) The optimal working dilution should be determined by the end user.
• Gene: ITGAM
• Gene Symbols: ITGAM
• Immunogen: Native purified ITGAM from human granulocytes.
• Regulatory Status: RUO
• Gene ID (Entrez): 3684
• Target Species: Human
• Form: Liquid

• Applications: Flow Cytometry
• Clone: MEM-174
• Description: Mouse monoclonal antibody raised against native ITGAM.
• Formulation: In PBS (0.2% BSA, 0.09% sodium azide)
• Gene Alias: CD11B/CR3A/MAC-1/MAC1A/MGC117044/MO1A/SLEB6
• Host Species: Mouse
• Quantity: 100 Reactions
• Primary or Secondary: Primary
• Test Specificity: This antibody recognizes CD11b antigen (Mac-1 alpha), a 165-170 KDa type I transmembrane protein mainly expressed on monocytes, granulocytes and NK-cells. The CD11b mediates neutrophil and monocyte interactions with stimulated endothelium.
• Content And Storage: Store in the dark at 4°C. Do not freeze.
  Avoid prolonged exposure to light.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG2a