ITGB2, Mouse, PE, Clone: MEM-48, Abnova™

Mouse monoclonal antibody raised against native ITGB2.

Supplier:  Abnova Corporation MAB4599

Catalog No. 89-111-924

Description

The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq

Specifications

• Antigen: ITGB2
• Classification: Monoclonal
• Conjugate: PE
• Dilution: Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 10⁶ cells in a suspension) The optimal working dilution should be determined by the end user.
• Gene: ITGB2
• Gene Symbols: ITGB2
• Immunogen: Native purified ITGB2 from leukocytes of patient suffering from LGL-type leukaemia.
• Regulatory Status: RUO
• Gene ID (Entrez): 3689
• Target Species: Human
• Form: Liquid

• Applications: Flow Cytometry
• Clone: MEM-48
• Description: Mouse monoclonal antibody raised against native ITGB2.
• Formulation: In PBS (0.2% BSA, 0.09% sodium azide)
• Gene Alias: CD18/LAD/LCAMB/LFA-1/MAC-1/MF17/MFI7
• Host Species: Mouse
• Quantity: 100 Reactions
• Primary or Secondary: Primary
• Test Specificity: This antibody MEM-48 recognizes an epitope involving residues 534-546 in cysteine-rich repeat 3 of the CD18 antigen (integrin β2 subunit; β2 integrin). CD18 is a 90-95 KDa type I transmembrane protein expressed on all leukocytes.
• Content And Storage: Store in the dark at 4°C. Do not freeze.
  Avoid prolonged exposure to light.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG1