KIR2DL4, Mouse, Clone: 2H6, Abnova™

Mouse monoclonal antibody raised against partial recombinant KIR2DL4.

Supplier:  Abnova Corporation MAB1059

Catalog No. 89-108-782

Description

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the framework loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

Specifications

• Antigen: KIR2DL4
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: Western Blot (1:500-1:2000) The optimal working dilution should be determined by the end user.
• Gene: KIR2DL4
• Gene Alias: CD158D/G9P/KIR103/KIR103AS
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Test Specificity: This antibody recognizes KIR2DL1, KIR2DL3, KIR2DL4 and KIR2DS4, members of killer cell immunoglobulin-like receptor family.
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG2b κ

• Applications: ELISA, Western Blot
• Clone: 2H6
• Description: Mouse monoclonal antibody raised against partial recombinant KIR2DL4.
• Formulation: In PBS, pH 7.4 (0.09% sodium azide)
• Gene Accession No.: NM_002255
• Gene Symbols: KIR2DL4
• Immunogen: Recombinant protein corresponding to amino acids 44-202 of human KIR2DL4.
• Regulatory Status: RUO
• Gene ID (Entrez): 3805
• Target Species: Human
• Form: Liquid