KIR2DL4, Mouse, PE, Clone: mAb 33, Abnova™

Catalog No.	Quantity
89-113-811	100 Reactions

Catalog No. 89-113-811 Supplier Abnova Corporation Supplier No. MAB9848

Description

Mouse monoclonal antibody raised against KIR2DL4.

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the framework loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

Specifications

• Antigen: KIR2DL4
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: mAb 33
• Conjugate: PE
• Description: Mouse monoclonal antibody raised against KIR2DL4.
• Dilution: Flow Cytometry (20 uL reagent/100 uL of whole blood or 10⁶ cells) The optimal working dilution should be determined by the end user.
• Formulation: In PBS, pH 7.4 (0.02% BSA, 0.09% sodium azide)
• Gene: KIR2DL4
• Gene Alias: CD158D/G9P/KIR103/KIR103AS
• Gene Symbols: KIR2DL4
• Host Species: Mouse
• Immunogen: NK3.3 cells and KIR2DL4-Ig fusion protein.
• Purification Method: Size-exclusion chromatography purification
• Quantity: 100 Reactions
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3805
• Test Specificity: The mouse monoclonal antibody mAb 33 recognizes extracellular portion of KIR2DL4 (CD158d), a 45 kDa NK cell marker. Cell surface expression and function of KIR2DL4 depends on genotype of particular individuals.
• Target Species: Human
• Content And Storage: Store in the dark at 4°C. Avoid prolonged exposure to light. Do not freeze.
• Form: Liquid
• Isotype: IgG1