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Description
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. [provided by RefSeq
Specifications
Specifications
| Antigen | KRT8 |
| Applications | Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot |
| Classification | Monoclonal |
| Clone | H1 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against KRT8. |
| Dilution | Flow Cytometry (0.5-1 ug/million cells) Immunofluorescence (1-2 ug/mL) Immunohistochemistry (1-2 ug/mL for 30 min at RT) Immunoprecipitation (1-2 ug/500 ug protein) Western Blot (0.25-0.5 ug/mL) The optimal working dilution should be determ |
| Formulation | In PBS, pH 7.4 (0.05% BSA, 0.05% sodium azide) |
| Gene | KRT8 |
| Gene Alias | CARD2/CK8/CYK8/K2C8/K8/KO |
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