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MilliporeSigma™ Mouse anti-LAG3, Clone: 8C7.1,

Catalog No. MABF294MI Shop All MilliporeSigma Products
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MABF294MI 100 μL
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Catalog No. MABF294MI Supplier MilliporeSigma™ Supplier No. MABF294
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Description

Mouse Monoclonal Antibody

Specifically detects LAG3 clone: 8C7.1 in Human samples, and it is validated for Flow Cytometry, Western Blotting

Lymphocyte activation gene 3 protein (UniProt P18627; also known as CD223, LAG-3, Protein FDC) is encoded by the LAG3 (also known as FDC) gene (Gene ID 3902) in human. LAG3 is a single-pass type I membrane protein that binds MHC class II molecules on antigen presenting cells with high affinity. LAG3 expression is induced after T cell activation and functions as a negative regulator of T cell function. LAG3 blockage is shown to augment T cell proliferation and cytokine production, and LAG3-deficient mice have a defect in the downregulation of T cell responses induced by staphylococcal enterotoxin B or by virus infection. In addition, LAG3 is expressed on activated regulatory T (Treg) cells at higher levels than on activated effector T cells. LAG3 blockage inhibits the suppressive activity of Treg cells. LAG3 is also upregulated on tumour-infiltrating lymphocytes (TILs), and LAG3 blockage can enhance anti-tumour T cell responses.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LAG3
Applications Flow Cytometry, Western Blot
Classification Monoclonal
Clone 8C7.1
Formulation Mouse monoclonal IgG2aκ antibody tissue culture supernatant with 0.05% sodium azide.
Gene Accession No. P18627
Gene Symbols LAG3; FDC
Host Species Mouse
Immunogen Mouse Fc-tagged recombinant human LAG3 extracellular fragment.
Purification Method Unpurified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Inflammation and Immunology
Primary or Secondary Primary
Gene ID (Entrez) NP_002277
Target Species Human
Content And Storage Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Form Supernatant
Isotype IgG2a κ
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For Research Use Only

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