LMNA, Mouse, Clone: 4E7, Abnova™

Catalog No.	Quantity
89-108-990	100 μL

Catalog No. 89-108-990 Supplier Abnova Corporation Supplier No. MAB10790

Description

Mouse monoclonal antibody raised against partial recombinant LMNA.

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq

Specifications

• Antigen: LMNA
• Applications: ELISA, Immunohistochemistry, Western Blot
• Classification: Monoclonal
• Clone: 4E7
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against partial recombinant LMNA.
• Dilution: ELISA (1:10000) Western Blot (1:500-1:2000) Immunohistochemistry (1:200-1:1000) The optimal working dilution should be determined by the end user.
• Formulation: In ascites (0.03% sodium azide)
• Gene: LMNA
• Gene Alias: CDCD1/CDDC/CMD1A/CMT2B1/EMD2/FPL/FPLD/HGPS/IDC/LDP1/LFP/LGMD1B/LMN1/LMNC/PRO1
• Gene Symbols: LMNA
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to human LMNA.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4000
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1