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LMNA, Mouse, Clone: JoL5, Abnova™

Catalog No. 89111040 Shop All Abnova Corporation Products
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89-111-040 2 mL
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Catalog No. 89-111-040 Supplier Abnova Corporation Supplier No. MAB2502
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Description

Mouse monoclonal antibody raised against recombinant LMNA.

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq

Specifications

Antigen LMNA
Applications Immunofluorescence, Western Blot
Classification Monoclonal
Clone JoL5
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against recombinant LMNA.
Dilution Western Blot (1:50) Immunofluorescence (1:10) The optimal working dilution should be determined by the end user.
Formulation In tissue culture supernatant (0.09% sodium azide)
Gene LMNA
Gene Alias CDCD1/CDDC/CMD1A/CMT2B1/EMD2/FPL/FPLD/HGPS/IDC/LDP1/LFP/LGMD1B/LMN1/LMNC/PRO1
Gene Symbols LMNA
Host Species Mouse
Immunogen Recombinant protein corresponding to human LMNA.
Quantity 2 mL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4000
Test Specificity Detects an un-phosphorylated form of LMNA and the epitope is mapped to the N-terminal head domain of both proteins.
Target Species Human, Mouse
Content And Storage Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG2
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