MilliporeSigma™ Mouse anti-M-Ras, Clone: 11F7.1,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABS1204

Catalog No. MABS1204

Description

Specifically detects M-Ras clone: 11F7.1 in Human samples, and it is validated for Western Blotting

Ras-related protein M-Ras (UniProt O14807; also known as Ras-related protein R-Ras3) is encoded by the MRAS (also known as RRAS3) gene (Gene ID 22808) in human. Originally characterized as a protein that is involved in actin filament reorganization-induced microspikes formation, M-Ras is a Ras superfamily member predominantly expressed in brain and less abundantly in skeletal muscle and heart. M-Ras and Ras share several common effector molecules, and M-Ras is reported to mediate NGF-stimulated ERK pathway signaling by activating B-Raf in PC12 cells. Unlike Ras, however, NGF-stimulation of PC12 cells results in a sustained activation of M-Ras, while only a trarnsient activation is observed with Ras. M-Ras is initially produced in a 208-amino acid proform, the 3 amino acids at the C-terminal end (a.a. 206-208) is removed posttranslationally to yield the mature protein.

Specifications

• Antigen: M-Ras
• Classification: Monoclonal
• Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: MRAS; RRAS3
• Immunogen: GST-tagged recombinant internal fragment from the C-terminal half of human M-Ras.
• Quantity: 100 μg
• Research Discipline: Signaling
• Gene ID (Entrez): NP_001078518
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Isotype: IgG1 κ

• Applications: Western Blot
• Clone: 11F7.1
• Gene Accession No.: O14807
• Host Species: Mouse
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Form: Purified

For Research Use Only