MAP2K2, Mouse, Clone: 7F5, Abnova™

Catalog No.	Quantity
89-108-992	100 μL

Catalog No. 89-108-992 Supplier Abnova Corporation Supplier No. MAB10792

Description

Mouse monoclonal antibody raised against partial recombinant MAP2K2.

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq

Specifications

• Antigen: MAP2K2
• Applications: ELISA, Flow Cytometry, Immunofluorescence, Western Blot
• Classification: Monoclonal
• Clone: 7F5
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against partial recombinant MAP2K2.
• Dilution: ELISA (1:10000) Western Blot (1:500-1:2000) Immunofluorescence (1:200-1:1000) Flow cytometry (1:200-1:400) The optimal working dilution should be determined by the end user.
• Formulation: In ascites (0.03% sodium azide)
• Gene: MAP2K2
• Gene Alias: FLJ26075/MAPKK2/MEK2/MKK2/PRKMK2
• Gene Symbols: MAP2K2
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to human MAP2K2.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5605
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1