MilliporeSigma™ Mouse anti-MAP2K2, Clone: 7F5,

Catalog No.	Quantity
MABS813MI	100 μL

Catalog No. MABS813MI Supplier MilliporeSigma™ Supplier No. MABS813

Description

Mouse Monoclonal Antibody

Specifically detects MAP2K2 clone: 7F5 in Human, Mouse, Rat samples, and it is validated for Flow Cytometry

Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2), also called MEK2, is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax.

Specifications

• Antigen: MAP2K2
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: 7F5
• Formulation: Mouse monoclonal IgG1 ascitic fluid containing 0.03% sodium azide.
• Gene Accession No.: P36507
• Gene Symbols: MAP2K2; MEK2; MKK2; PRKMK2
• Host Species: Mouse
• Immunogen: Purified recombinant fragment of human MAP2K2 expressed in E. coli.
• Purification Method: Unpurified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Signaling
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
• Form: Ascites
• Isotype: IgG1

For Research Use Only