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MAP3K5, Mouse, Clone: 2E4, Abnova™

Catalog No. 89108998 Shop All Abnova Corporation Products
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89-108-998 100 μL
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Catalog No. 89-108-998 Supplier Abnova Corporation Supplier No. MAB10798
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Description

Mouse monoclonal antibody raised against partial recombinant MAP3K5.

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq

Specifications

Antigen MAP3K5
Applications ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
Classification Monoclonal
Clone 2E4
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against partial recombinant MAP3K5.
Dilution ELISA (1:10000) Western Blot (1:500-1:2000) Immunohistochemistry (1:200-1:1000) Immunofluorescence (1:200-1:1000) Flow cytometry (1:200-1:400) The optimal working dilution should be determined by the end user.
Formulation In ascites (0.03% sodium azide)
Gene MAP3K5
Gene Alias ASK1/MAPKKK5/MEKK5
Gene Symbols MAP3K5
Host Species Mouse
Immunogen Recombinant protein corresponding to human MAP3K5.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4217
Target Species Human
Content And Storage Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG1
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