MAPK10, Mouse, Clone: 10E4A4, Abnova™

Catalog No.	Quantity
89-108-791	100 μL

Catalog No. 89-108-791 Supplier Abnova Corporation Supplier No. MAB10598

Description

Mouse monoclonal antibody raised against partial recombinant MAPK10.

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq

Specifications

• Antigen: MAPK10
• Applications: ELISA, Immunofluorescence, Western Blot
• Classification: Monoclonal
• Clone: 10E4A4
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against partial recombinant MAPK10.
• Dilution: ELISA (1:10000) Western Blot (1:500-1:2000) Immunofluorescence (1:200-1:1000) The optimal working dilution should be determined by the end user.
• Formulation: In ascites (0.03% sodium azide)
• Gene: MAPK10
• Gene Alias: FLJ12099/FLJ33785/JNK3/JNK3A/MGC50974/PRKM10/p493F12/p54bSAPK
• Gene Symbols: MAPK10
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acids 28-233 of human MAPK10.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5602
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1