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MilliporeSigma™ Mouse anti-MAPK10, Clone: 10E4A4,

Catalog No. MABN1176MI Shop All MilliporeSigma Products
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MABN1176MI 100 μL
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Catalog No. MABN1176MI Supplier MilliporeSigma™ Supplier No. MABN1176
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Description

Mouse Monoclonal Antibody

Specifically detects MAPK10 clone: 10E4A4 in Human samples, and it is validated for Immunocytochemistry

mitogen-activated protein kinase 10 (MAPK10), also known as JNK3, JNK3A, PRKM10, p54bSAPK, is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAPK10 is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MAPK10
Applications Immunocytochemistry
Classification Monoclonal
Clone 10E4A4
Formulation Mouse monoclonal IgG1 ascitic fluid containing 0.03% sodium azide.
Gene Accession No. P53779
Gene Symbols MAPK10; JNK3; JNK3A; PRKM10; SAPK1B
Host Species Mouse
Immunogen Purified recombinant fragment of human MAPK10 expressed in E. coli.
Purification Method Unpurified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Target Species Human
Content And Storage Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Form Ascites
Isotype IgG1
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For Research Use Only

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