MAPK10, Mouse, Clone: 2G12H3, Abnova™

Catalog No.	Quantity
89-112-284	100 μg

Catalog No. 89-112-284 Supplier Abnova Corporation Supplier No. MAB5533

Description

Mouse monoclonal antibody raised against partial recombinant MAPK10.

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq

Specifications

• Antigen: MAPK10
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 2G12H3
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against partial recombinant MAPK10.
• Dilution: Western Blot (1:500-1:1000) ELISA (1:10000) The optimal working dilution should be determined by the end user.
• Formulation: In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
• Gene: MAPK10
• Gene Alias: FLJ12099/FLJ33785/JNK3/JNK3A/MGC50974/PRKM10/p493F12/p54bSAPK
• Gene Symbols: MAPK10
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to human MAPK10.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5602
• Target Species: Human
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1