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Description
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq
Specifications
Specifications
| Antigen | MATK |
| Applications | ELISA, Flow Cytometry, Western Blot |
| Classification | Monoclonal |
| Clone | 9D7 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against partial recombinant MATK. |
| Dilution | ELISA (1:10000) Western Blot (1:500-1:2000) Flow cytometry (1:200-1:400) The optimal working dilution should be determined by the end user. |
| Formulation | In PBS (50% glycerol, 0.03% sodium azide) |
| Gene | MATK |
| Gene Alias | CHK/CTK/DKFZp434N1212/HHYLTK/HYL/HYLTK/Lsk/MGC1708/MGC2101 |
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