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MBS/MYPT1, Mouse, Clone: AF-20, Abnova™

Catalog No. 89107813 Shop All Abnova Corporation Products
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Catalog No. Quantity
89-107-813 100 μg
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Catalog No. 89-107-813 Supplier Abnova Corporation Supplier No. MAB0001

Description

Mouse monoclonal antibody raised against synthetic phosphopeptide of MBS/MYPT1.

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Specifications

Antigen MBS/MYPT1
Applications ELISA, Immunofluorescence, Western Blot
Classification Monoclonal
Clone AF-20
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against synthetic phosphopeptide of MBS/MYPT1.
Dilution Western Blot (1-2 ug/mL) ELISA (1 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In 10mM HEPES/KOH, 150mM NaCl, pH 7.5 (50% glycerol)
Gene PPP1R12A
Gene Accession No. D87930
Gene Alias MBS/MGC133042/MYPT1
Gene Symbols PPP1R12A
Host Species Mouse
Immunogen Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T696 of human MBS/MYPT1.
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4659
Target Species Chicken, Human, Mouse, Rat
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG1
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