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MilliporeSigma™ Mouse anti-Mcpip1, Clone: 2H8.2,

Catalog No. MABS430MI Shop All MilliporeSigma Products
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MABS430MI 100 μg
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Catalog No. MABS430MI Supplier MilliporeSigma™ Supplier No. MABS430
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Description

Mouse Monoclonal Antibody

Specifically detects Mcpip1 clone: 2H8.2 in Human samples, and it is validated for Immunocytochemistry, Immunohistochemistry (Paraffin)

MCP-induced protein 1 (also known as ribonuclease ZC3H12A, Zinc finger CCCH domain-containing protein 12A) is encoded by the ZC3H12A gene in human (also known as dJ423B22.1, MCPIP, MCPIP1). It belongs to the 4-member CCCH-zinc finger protein family (MCPIP1/2/3/4) that act as negative regulators in macrophage activation (PMID 18178554). MCPIP1 in particular is involved in immune response downregulation upon LPS treatment by targeting IL-6 and IL-12b with its RNase activity (PMID 22561375). MCPIP1 expresssion by MCP-1 treatment is reported to promote angiogenesis in human umbilical vein endothelial cell (HUVEC) cultures, while causing apoptotic cell death in cardiac myocytes (PMID 18364357 & 16574901).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Mcpip1
Applications Immunocytochemistry, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 2H8.2
Formulation Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. Q5D1E8
Gene Symbols ZC3H12A; MCPIP; MCPIP1
Host Species Mouse
Immunogen GST-tagged recombinant protein corresponding to human Mcpip1.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Signaling
Primary or Secondary Primary
Gene ID (Entrez) NP_079355
Target Species Human
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG2a κ
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For Research Use Only

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