MLL, Mouse, Clone: 10F8D7, Abnova™

Mouse monoclonal antibody raised against partial recombinant MLL.

Supplier:  Abnova Corporation MAB10562

Catalog No. 89-108-753

Description

The MLL gene encodes a DNA-binding protein that methylates histone H3 (see MIM 601128) lys4 (H3K4) and positively regulates expression of target genes, including multiple HOX genes (see MIM 142980). MLL is a frequent target for recurrent translocations in acute leukemias that may be characterized as acute myeloid leukemia (AML; MIM 601626), acute lymphoblastic leukemia (ALL), or mixed lineage (biphenotypic) leukemia (MLL). Leukemias with translocations involving MLL possess unique clinical and biologic characteristics and are often associated with poor prognosis. MLL rearrangements are found in more than 70% of infant leukemias, whether the immunophenotype is more consistent with ALL or AML6, but are less frequent in leukemias from older children. MLL translocations are also found in approximately 10% of AMLs in adults, as well as in therapy-related leukemias, most often characterized as AML, that develop in patients previously treated with topoisomerase II inhibitors for other malignancies. More than 50 different MLL fusion partners have been identified. Leukemogenic MLL translocations encode MLL fusion proteins that have lost H3K4 methyltransferase activity. A key feature of MLL fusion proteins is their ability to efficiently transform hematopoietic cells into leukemia stem cells (Krivtsov and Armstrong, 2007 [PubMed 17957188]).[supplied by OMIM

Specifications

• Antigen: MLL
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:10000) Western Blot (1:500-1:2000) Immunohistochemistry (1:200-1:1000) The optimal working dilution should be determined by the end user.
• Gene: MLL
• Gene Symbols: MLL
• Immunogen: Recombinant protein corresponding to amino acids 3751-3968 of human MLL.
• Regulatory Status: RUO
• Gene ID (Entrez): 4297
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG1

• Applications: ELISA, Immunohistochemistry, Western Blot
• Clone: 10F8D7
• Description: Mouse monoclonal antibody raised against partial recombinant MLL.
• Formulation: In ascites (0.03% sodium azide)
• Gene Alias: ALL-1/CXXC7/FLJ11783/HRX/HTRX1/KMT2A/MLL/GAS7/MLL1A/TET1-MLL/TRX1
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid