MilliporeSigma™ Mouse anti-MTSS1, Clone: 15C3.2,

Catalog No.	Quantity
MABC607MI	100 μg

Catalog No. MABC607MI Supplier MilliporeSigma™ Supplier No. MABC607

Description

Mouse Monoclonal Antibody

Specifically detects MTSS1 clone: 15C3.2 in Human, Monkey samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting

Metastasis suppressor protein 1 (UniProt O43312; also known as Metastasis suppressor YGL-1, Missing in metastasis protein) is encoded by the MTSS1 (also known as KIAA0429, MIM) gene (Gene ID 9788) in human. MTSS1 is a scaffold protein that regulates cytoskeletal dynamics and actin polymerization. MTSS1 is also reported to bind Gli proteins or the Gli-Sufu complex and potentiate the transcription of effector genes of the sonic hedgehog signaling pathway. MTSS1 is down-regulated in many metastatic cancer cells compared with their non-metastatic counterparts. MTSS1 expression is shown to be inversely correlated with the prognosis of solid carcinomas of the breast, liver, and bladder.

Specifications

• Antigen: MTSS1
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: 15C3.2
• Formulation: Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: O43312
• Gene Symbols: MTSS1; KIAA0429; MIM
• Host Species: Mouse
• Immunogen: GST-tagged recombinant protein corresponding to the C-terminal of human MTSS1.
• Purification Method: Protein G Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Apoptosis, Cancer
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_055566
• Target Species: Human, Monkey
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Form: Purified
• Isotype: IgG2a κ

For Research Use Only