MYH11, Mouse, Clone: S131, Abnova™

Catalog No.	Quantity
89-113-666	3 x 1 mL

Catalog No. 89-113-666 Supplier Abnova Corporation Supplier No. MAB9497

Description

Mouse monoclonal antibody raised against native MYH11.

The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of nonidentical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

Specifications

• Antigen: MYH11
• Applications: Immunohistochemistry, Immunohistochemistry (Frozen)
• Classification: Monoclonal
• Clone: S131
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against native MYH11.
• Dilution: Immunohistochemistry (1:100-1:200) The optimal working dilution should be determined by the end user.
• Formulation: Lyophilized from tissue culture supernatant (0.09% sodium azide)
• Gene: MYH11
• Gene Alias: AAT4/DKFZp686D10126/DKFZp686D19237/FAA4/FLJ35232/MGC126726/MGC32963/SMHC/SMMHC
• Gene Symbols: MYH11
• Host Species: Mouse
• Immunogen: Native MYH11 from human smooth muscle.
• Quantity: 3 x 1 mL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4629
• Target Species: Human
• Content And Storage: Store at 4°C on dry atmosphere. After reconstitution with sterile distilled water store at 4°C for at least two months. For long term storage store at -20°C or below. Aliquot to avoid repeated freezing and thawing.
• Form: Lyophilized
• Isotype: IgG2b κ