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Description
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq
Specifications
Specifications
| Antigen | NEFH |
| Applications | Immunohistochemistry (PFA fixed) |
| Classification | Monoclonal |
| Clone | RT-97 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against NEFH. |
| Dilution | Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:400) The optimal working dilution should be determined by the end user. |
| Formulation | In PBS (0.05% BSA, 0.05% sodium azide) |
| Gene | NEFH |
| Gene Alias | NFH |
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