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Description
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq
Specifications
Specifications
| Antigen | NEFL |
| Applications | ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot |
| Classification | Monoclonal |
| Clone | 1H3 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against partial recombinant NEFL. |
| Dilution | ELISA (1:10000) Western Blot (1:500-1:2000) Immunohistochemistry (1:200-1:1000) Immunofluorescence (1:200-1:1000) Flow cytometry (1:200-1:400) The optimal working dilution should be determined by the end user. |
| Formulation | In PBS (0.5% protein stabilizer, 0.05% sodium azide) |
| Gene | NEFL |
| Gene Alias | CMT1F/CMT2E/FLJ53642/NF-L/NF68/NFL |
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