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Description
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq
Specifications
Specifications
| Antigen | NF1 |
| Applications | ELISA, Immunohistochemistry, Immunoprecipitation |
| Classification | Monoclonal |
| Clone | McNFn27 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against synthetic peptide of NF1. |
| Dilution | Immunohistochemistry (10-20 ug/mL) The optimal working dilution should be determined by the end user. |
| Formulation | In PBS (0.05% sodium azide) |
| Gene | NF1 |
| Gene Alias | DKFZp686J1293/FLJ21220/NFNS/VRNF/WSS |
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