NLRP3, Mouse, Clone: Nalpy3-b, Abnova™

Catalog No.	Quantity
89-111-563	100 μg

Catalog No. 89-111-563 Supplier Abnova Corporation Supplier No. MAB3724

Description

Mouse monoclonal antibody raised against recombinant NLRP3.

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq]

Specifications

• Antigen: NLRP3
• Applications: Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
• Classification: Monoclonal
• Clone: Nalpy3-b
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against recombinant NLRP3.
• Dilution: Western Blot (1:1000) Immunoprecipitation (1:50) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.02% sodium azide)
• Gene: NLRP3
• Gene Alias: AGTAVPRL/AII/AII/AVP/AVP/C1orf7/CIAS1/CLR1.1/FCAS/FCU/FLJ95925/MWS/NALP3/PYPAF1
• Gene Symbols: NLRP3
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to human NLRP3.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 114548
• Test Specificity: Recognizes human NALP3. Detects endogenous proteins by IP and WB.
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1