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MilliporeSigma™ Mouse anti-NOS1AP, Clone: 6E1.1,

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MABN229MI 100 μg
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Description

Mouse Monoclonal Antibody

Specifically detects NOS1AP clone: 6E1.1 in Human, Mouse, Rat samples, and it is validated for Immunohistochemistry, Western Blotting

Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase(nNOS) protein or CAPON (UniProt O75052), also known as Nitric oxide synthase (NOS) 1 adaptor protein, C-terminal PDZ ligand of nNOS, C-terminal PDZ domain ligand of nNOS, Ligand of nNOS with carboxyl-terminal PDZ domain) is a cytosolic protein encoded by the NOS1AP gene (Entrez Gene ID 9722) in human. NOS1AP protein (CAPON) contains a C-terminal PDZ-binding domain and an N-terminal phosphotyrosine binding (PTB) domain that mediates its interactions with nNOS and the small monomeric G protein Dexras1, respectively. Originally it was characterized as a competitor against PSD95 for nNOS interaction, but later evidence indicates that nNOS-CAPON association contributes to the modulation of anxiety-related behavior via regulating Dexras1-ERK signaling. CAPON is also reported to co-localize with the L-type calcium channel and the inwardly rectifying potassium channel Kir3.1 in murine cardiac myocytes. In addition, CAPON is significantly upregulated in mice with dystrophic cardiomyopathy, implicating a role of NOS1AP protein on cardiac arrhythmias, most likely through S-nitrosylation of L-type calcium channel and potassium channels.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOS1AP
Applications Immunohistochemistry, Western Blot
Classification Monoclonal
Clone 6E1.1
Formulation Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. O75052
Gene Symbols NOS1AP; CAPON; KIAA0464
Host Species Mouse
Immunogen GST-tagged recombinant protein corresponding to the C-terminal of human NOS1AP.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_055512
Target Species Human, Mouse, Rat
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG2b κ
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