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Description
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq
Specifications
Specifications
| Antigen | NTRK1 |
| Applications | ELISA, Immunofluorescence, Western Blot |
| Classification | Monoclonal |
| Clone | 6B2 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against recombinant NTRK1. |
| Dilution | Western Blot (1:500-1:2000) Immunofluorescence (1:200-1:1000) ELISA (1:10000) The optimal working dilution should be determined by the end user. |
| Formulation | In ascitic (0.03% sodium azide) |
| Gene | NTRK1 |
| Gene Alias | DKFZp781I14186/MTC/TRK/TRK1/TRKA/p140-TrkA |
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