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MilliporeSigma™ Mouse anti-Oct-1 (Ascites Free), Clone: YL15,

Catalog No. MAB5434C Shop All MilliporeSigma Products
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MAB5434C 100 μg
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Description

Mouse Monoclonal Antibody

Specifically detects Oct-1 (Ascites Free) clone: YL15 in Human, Mouse samples, and it is validated for ChIP, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blotting

POU domain, class 2, transcription factor 1 (UniProt P14859; also known as NF-A1, Oct-1, Octamer-binding protein 1, Octamer-binding transcription factor 1, OTF-1) is encoded by the POU2F1 (also known as OCT1, OTF1) gene (Gene ID 5451) in human. Oct-1 belongs to the family of octamer transcription factors characterized by their binding to the ATTTGCAT octamer sequence via their POU domain (a.a. 280-354 of human Oct-1). Oct1 is widely expressed in adult tissues, however, Oct-1 knockdown has little impact on cell growth and viability in culture. Oct-1 controls multiple stem cell phenotypes in normal and tumor cells. Oct-1 promotes resistance to genotoxic and oxidative stresses in stem cells. Loss of Oct-1 antagonizes oncogenic transformation in vitro and tumorigenicity in vivo.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Oct-1 (Ascites Free)
Applications ChIP Assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone YL15
Formulation Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. P14859
Gene Symbols POU2F1; OCT1; OTF1
Host Species Mouse
Immunogen Recombinant full-length human Oct-1.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Epigenetics and Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NP_001185712
Target Species Human, Mouse
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG1 κ
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For Research Use Only

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