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MilliporeSigma™ Mouse anti-Oct-1 (Ascites Free), Clone: YL15,
Mouse Monoclonal Antibody
Supplier: MilliporeSigma™ MAB5434C
Description
Specifically detects Oct-1 (Ascites Free) clone: YL15 in Human, Mouse samples, and it is validated for ChIP, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blotting
POU domain, class 2, transcription factor 1 (UniProt P14859; also known as NF-A1, Oct-1, Octamer-binding protein 1, Octamer-binding transcription factor 1, OTF-1) is encoded by the POU2F1 (also known as OCT1, OTF1) gene (Gene ID 5451) in human. Oct-1 belongs to the family of octamer transcription factors characterized by their binding to the ATTTGCAT octamer sequence via their POU domain (a.a. 280-354 of human Oct-1). Oct1 is widely expressed in adult tissues, however, Oct-1 knockdown has little impact on cell growth and viability in culture. Oct-1 controls multiple stem cell phenotypes in normal and tumor cells. Oct-1 promotes resistance to genotoxic and oxidative stresses in stem cells. Loss of Oct-1 antagonizes oncogenic transformation in vitro and tumorigenicity in vivo.
Specifications
Oct-1 (Ascites Free) | |
Monoclonal | |
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide. | |
POU2F1; OCT1; OTF1 | |
Recombinant full-length human Oct-1. | |
100 μg | |
Epigenetics and Nuclear Function | |
NP_001185712 | |
Stable for one year at 2°C to 8°C from date of receipt. | |
IgG1 κ |
ChIP Assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
YL15 | |
P14859 | |
Mouse | |
Protein G Purified | |
RUO | |
Primary | |
Human, Mouse | |
Purified |
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