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MilliporeSigma™ Mouse anti-PAFAH 1B3, Clone: 3E4.1,

Catalog No. MABS1188 Shop All MilliporeSigma Products
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MABS1188 100 μg
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Description

Mouse Monoclonal Antibody

Specifically detects PAFAH 1B3 clone: 3E4.1 in Human, Mouse samples, and it is validated for Immunocytochemistry, Western Blotting

Platelet-activating factor acetylhydrolase IB subunit gamma (EC 3.1.1.47; UniProt Q15102; also known as PAF acetylhydrolase 29kDa subunit, PAF-AH 29kDa subunit, PAF-AH1b subunit alpha 1, PAF-AH subunit gamma, PAFAH subunit gamma) is encoded by the PAFAH1B3 (also known as PAFAHG) gene (Gene ID 5050) in human. Platelet-activating factor (PAF) acetylhydrolase (PAF-AH) negatively regulates PAF potency by catalyzing the removal of the acetyl group at the sn-2 position of the lipid messenger. There are two types of intracellular PAF-AH and a plasma type PAF-AH. Type I intracellular PAF-AH is a heterotrimeric G-protein-like complex composed of alpha1 (originally called gamma), alph2 (originally called alpha), and beta subunits. Both alpha1 and alpha2 contains a catalytic site. The alpha2/2 homodimer hydrolyzes PAF (1-O-alkyl-2-acetyl-sn-glycero-3-PC) and 1-O-alkyl-2-acetyl-sn-glycero-3-PE more efficiently, while the alpha1/1 homodimer and alpha1/2 heterodimer are more efficient toward 1-O-alkyl-2-acetyl-sn-glycero-3-PA than PAF. The alpha 1 subunit is reported to be up-regulated in primary human breast tumors and correlated with poor prognosis. Inactivation of alpha 1 subunit enhances cellular level of tumor-suppressing signaling lipids.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PAFAH 1B3
Applications Immunocytochemistry, Western Blot
Classification Monoclonal
Clone 3E4.1
Formulation Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. Q15102
Gene Symbols PAFAH1B3; PAFAHG
Host Species Mouse
Immunogen GST-tagged recombinant internal fragment from the C-terminal half of human PAFAH1B3.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Signaling
Primary or Secondary Primary
Gene ID (Entrez) NP_001139411
Target Species Human, Mouse
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG2b κ
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