MilliporeSigma™ Mouse anti-pan-AMPA receptor (GluR1-4), Clone: 2D8,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABN832

Catalog No. MABN832MI

Description

Specifically detects pan-AMPA receptor (GluR1-4) clone: 2D8 in Human, Rat samples, and it is validated for Electron Microscopy, ELISA, Enzyme Immunoassay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blotting

Glutamate receptors are synaptic receptors located primarily on the membranes of neuronal cells. Upon ligand stimulation, ionotropic glutamate receptors (iGluRs) form non-selective cation channels, while metabotropic glutamate receptors (mGluRs) indirectly activate ion channels via G protein-mediated signaling. AMPA receptors are iGluRs and are also known as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, AMPARs, or quisqualate receptors. AMPARs are composed of four types of subunits, GluR1/GluA1 (UniProt P42261) is encoded by GRIA1, GluR2/GluA2 (UniProt P42262) by GRIA2, GluR3/GluA3 (UniProt P42263) by GRIA3, and GluR4/GluA4 (UniProt P48058) by GRIA4 gene in human. AMPARs are tetrameric in nature, consisting of two sets of homodimers, most often a set of GluR2 dimer is coupled with a set of GluR1, GluR3 or GluR4 homodimer. Anti-pan-AMPA receptor (GluR1-4), clone 2D8, reacts with all four AMPA receptor subunits.

Specifications

• Antigen: pan-AMPA receptor (GluR1-4)
• Classification: Monoclonal
• Formulation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: GRIA1; GLUH1; GLUR1
• Immunogen: Fusion protein coding for the extracellular domain of AMPA Glutamate receptor 1-4 corresponding to human pan-AMPA receptor (GluR1-4).
• Quantity: 100 μg
• Research Discipline: Neuroscience
• Gene ID (Entrez): NP_000818; NP_000817; NP_000819; NP_000820
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Isotype: IgG2b κ

• Applications: Immunoassay, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
• Clone: 2D8
• Gene Accession No.: P42261; P42262; P42263; P48058
• Host Species: Mouse
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Form: Purified

For Research Use Only