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PAX5, Mouse, Clone: 1EW, Abnova™

Catalog No. 89113710 Shop All Abnova Corporation Products
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89-113-710 3 x 1 mL
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Catalog No. 89-113-710 Supplier Abnova Corporation Supplier No. MAB9628

Description

Mouse monoclonal antibody raised against partial recombinant PAX5.

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined. [provided by RefSeq

Specifications

Antigen PAX5
Applications Immunohistochemistry, Western Blot
Classification Monoclonal
Clone 1EW
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against partial recombinant PAX5.
Dilution Immunohistochemistry (1:20-1:40) Western Blot (1:100-1:250) The optimal working dilution should be determined by the end user.
Formulation In tissue culture supernatant (0.09% sodium azide)
Gene PAX5
Gene Alias BSAP
Gene Symbols PAX5
Host Species Mouse
Immunogen Recombinant protein corresponding to C-terminus of human PAX5.
Quantity 3 x 1 mL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5079
Target Species Human
Content And Storage Store at 4°C. Do not freeze.
Form Liquid
Isotype IgG1
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