MilliporeSigma™ Mouse anti-PD-1, Clone: 16A2.1,

Catalog No.	Quantity
MABF261MI	100 μg

Catalog No. MABF261MI Supplier MilliporeSigma™ Supplier No. MABF261

Description

Mouse Monoclonal Antibody

Specifically detects PD-1 clone: 16A2.1 in Human samples, and it is validated for Flow Cytometry, Western Blotting

Programmed cell death protein 1 (PD-1) (UniProt Q15116), also known as CD279, hPD-1, hPD-I, hSLE1, Protein PD-1, Systemic lupus erythematosus susceptibility 2) is a type I single transmembrane protein encoded by the PDCD1 gene in human. Maintenance of peripheral tolerance by preventing the development of autoimmunity due to T lymphocytes specific for self-antigens is essential for homeostasis of the immune system. PD-1 receptor CD279 and its ligands PD-L1 (B7-H1, CD274) and PD-L2 (B7-DC; CD273) play a vital role in the induction and maintenance of peripheral tolerance. Upregulated PD-1 expression is seen on conventional CD4+ CD25- T cells (Tconv) when exposed to mesenchymal stem cells, resulting in increased Tconv apoptosis due to PD-1 stimulation by the MSC PD-L2.

Specifications

• Antigen: PD-1
• Applications: Flow Cytometry, Western Blot
• Classification: Monoclonal
• Clone: 16A2.1
• Formulation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: Q15116
• Gene Symbols: PDCD1; PD1
• Host Species: Mouse
• Immunogen: KLH-conjugated linear peptide corresponding to the extracellular domain of human PD-1.
• Purification Method: Protein G Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Inflammation and Immunology
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_005009
• Target Species: Human
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Form: Purified
• Isotype: IgG2a κ

For Research Use Only