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PFKM, Mouse, Clone: AT2F11, Abnova™

Catalog No. 89109374 Shop All Abnova Corporation Products
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89-109-374 100 μL
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Catalog No. 89-109-374 Supplier Abnova Corporation Supplier No. MAB11205
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Description

Mouse monoclonal antibody raised against partial recombinant PFKM.

The PFKM gene encodes the muscle isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. Mammalian PFK is a tetramer made up of various combinations of 3 subunits: muscle (PFKM), liver (PFKL; MIM 171860), and platelet (PFKP; MIM 171840), the genes for which are located on chromosomes 12q13, 21q22, and 10p, respectively. The composition of the tetramers differs according to the tissue type. Muscle and liver PFK are a homotetramers of 4M and 4L subunits, respectively. Erythrocytes contain both L and M subunits, which randomly tetramerize to form M4, L4, and M3L, M2L2, and ML3 hybrid forms of the holoenzyme (Vora et al., 1980 [PubMed 6444721]; Raben and Sherman, 1995 [PubMed 7550225]).[supplied by OMIM

Specifications

Antigen PFKM
Applications ELISA, Western Blot
Classification Monoclonal
Clone AT2F11
Concentration 1 mg/mL
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against partial recombinant PFKM.
Dilution Western Blot (1:500-1:2000) The optimal working dilution should be determined by the end user.
Formulation In Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 0.01% Sodium Azide.
Gene PFKM
Gene Alias GSD7/MGC8699/PFK-1/PFK-M/PFKX
Gene Symbols PFKM
Host Species Mouse
Immunogen Recombinant protein corresponding to amino acids 1-780 of human PFKM.
Purification Method Protein A purification
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5213
Target Species Human
Content And Storage Store at 4°C. For long term storage aliquot and store at -20°C. Avoid repeated freezing and thawing cycles.
Form Liquid
Isotype IgG2a κ
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