MilliporeSigma™ Mouse anti-Pim-1, Clone: 19F7,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABC553

Catalog No. MABC553MI

Description

Specifically detects Pim-1 clone: 19F7 in Human samples, and it is validated for Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blotting

Pim-1 is a serine/threonine protein kinase encoded by the PIM1 (or PIM) gene in human. Pim-1 is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).

Specifications

• Antigen: Pim-1
• Classification: Monoclonal
• Formulation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: PIM1
• Immunogen: Conjugated linear peptide corresponding to the C-terminus of human Pim-1.
• Quantity: 100 μg
• Research Discipline: Apoptosis, Cancer
• Gene ID (Entrez): NP_001230115
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Isotype: IgG2a κ

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: 19F7
• Gene Accession No.: P11309
• Host Species: Mouse
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Form: Purified

For Research Use Only