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MilliporeSigma™ Mouse anti-Pim-1, Clone: 19F7,

Catalog No. MABC553MI Shop All MilliporeSigma Products
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MABC553MI 100 μg
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Catalog No. MABC553MI Supplier MilliporeSigma™ Supplier No. MABC553
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Description

Mouse Monoclonal Antibody

Specifically detects Pim-1 clone: 19F7 in Human samples, and it is validated for Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blotting

Pim-1 is a serine/threonine protein kinase encoded by the PIM1 (or PIM) gene in human. Pim-1 is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Pim-1
Applications Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 19F7
Formulation Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. P11309
Gene Symbols PIM1
Host Species Mouse
Immunogen Conjugated linear peptide corresponding to the C-terminus of human Pim-1.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Apoptosis, Cancer
Primary or Secondary Primary
Gene ID (Entrez) NP_001230115
Target Species Human
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG2a κ
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For Research Use Only

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