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PML, Mouse, Clone: B4C8, Abnova™

Catalog No. 89113363 Shop All Abnova Corporation Products
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500 μg
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89-113-363 500 μg
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Catalog No. 89-113-363 Supplier Abnova Corporation Supplier No. MAB8132
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Description

Mouse monoclonal antibody raised against recombinant PML.

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

Specifications

Antigen PML
Applications ELISA, Western Blot
Classification Monoclonal
Clone B4C8
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against recombinant PML.
Dilution The optimal working dilution should be determined by the end user.
Formulation Lyophilized from 10mM PBS
Gene PML
Gene Alias MYL/PP8675/RNF71/TRIM19
Gene Symbols PML
Host Species Mouse
Immunogen Recombinant protein corresponding to human PML.
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5371
Target Species Human
Content And Storage Store at -20°C.
Aliquot after reconstitution to avoid repeated freezing and thawing.
Form Lyophilized
Isotype IgG1
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