POMC, Mouse, Clone: 57, Abnova™

Catalog No.	Quantity
89-109-512	100 μg

Catalog No. 89-109-512 Supplier Abnova Corporation Supplier No. MAB11348

Description

Mouse monoclonal antibody raised against POMC.

This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq

Specifications

• Antigen: POMC
• Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
• Classification: Monoclonal
• Clone: 57
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against POMC.
• Dilution: Flow Cytometry (0.5-1 ug/million cells) Immunofluorescence (1-2 ug/mL) Immunohistochemistry (1-2 ug/mL for 30 min at RT) Immunoprecipitation (1-2 ug/500 ug protein) Western Blot (0.25-0.5 ug/mL) The optimal working dilution should be determ
• Formulation: In PBS, pH 7.4 (0.05% BSA, 0.05% sodium azide)
• Gene: POMC
• Gene Alias: ACTH/CLIP/LPH/MSH/NPP/POC
• Gene Symbols: POMC
• Host Species: Mouse
• Immunogen: N-terminal fragment of human POMC conjugated to KLH.
• Purification Method: Protein A/G affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5443
• Target Species: Human, Rat
• Content And Storage: Store at 4°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1 κ