POMC, Mouse, Clone: B31.15, Abnova™

Catalog No.	Quantity
89-108-233	100 μg

Catalog No. 89-108-233 Supplier Abnova Corporation Supplier No. MAB0905

Description

Mouse monoclonal antibody raised against native POMC.

This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq

Specifications

• Antigen: POMC
• Applications: Immunohistochemistry, Immunohistochemistry (Frozen)
• Classification: Monoclonal
• Clone: B31.15
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against native POMC.
• Dilution: The optimal working dilution should be determined by the end user.
• Formulation: In PBS, pH 7.4 (0.09% sodium azide)
• Gene: POMC
• Gene Alias: ACTH/CLIP/LPH/MSH/NPP/POC
• Gene Symbols: POMC
• Host Species: Mouse
• Immunogen: Native purified human POMC.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5443
• Target Species: Human
• Content And Storage: Store at 4°C. Do not freeze.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1