PPM1A, Mouse, Clone: p6c7, Abnova™

Catalog No.	Quantity
89-108-685	100 μL

Catalog No. 89-108-685 Supplier Abnova Corporation Supplier No. MAB1050

Description

Mouse monoclonal antibody raised against full-length recombinant PPM1A.

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq

Specifications

• Antigen: PPM1A
• Applications: ELISA, Immunoprecipitation, Western Blot
• Classification: Monoclonal
• Clone: p6c7
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against full length recombinant PPM1A.
• Dilution: Western Blot (1:250-1:1000) The optimal working dilution should be determined by the end user.
• Formulation: In PBS, pH 7.4 (0.09% sodium azide)
• Gene: PPM1A
• Gene Accession No.: NM_177952
• Gene Alias: FLJ42306/MGC9201/PP2C-ALPHA/PP2CA
• Gene Symbols: PPM1A
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to full length human PPM1A.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5494
• Target Species: Human, Mouse
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG2b κ