MilliporeSigma™ Mouse anti-PRDM5, Clone: 57-20,

Catalog No.	Quantity
MABE972MI	200 μg

Catalog No. MABE972MI Supplier MilliporeSigma™ Supplier No. MABE972

Description

Mouse Monoclonal Antibody

Specifically detects PRDM5 clone: 57-20 in Mouse samples, and it is validated for Immunoprecipitation, Western Blotting

PR domain zinc finger protein 5 (UniProt Q9NQX1) is encoded by the PRDM1 gene (also known as BCS2, PFM2) in human (Gene ID 11107). PRDM proteins constitute a family of transcriptional regulators that are characterized by the presence of variable numbers of zinc finger domains and an N-terminal PR domain. PRDM5 can negatively regulate gene transcriptions by recruiting the G9a histone methyltransferase and histone deacetylases. PRDM5 can promote transcription by targeting enhancer-like elements or recruiting RNA polymerase II binding. PRDM5 is highly expressed in murine embryonic stem cells (mESCs) and associates with complexes involved in chromatin organization, such as Ctcf, Smc1 (cohesin), and TFIIIC, which indicates their involvement in chromatin organization. PRDM5 is often found silenced in human breast, ovarian, liver, and cervical cancers.

Specifications

• Antigen: PRDM5
• Applications: Immunoprecipitation, Western Blot
• Classification: Monoclonal
• Clone: 57-20
• Formulation: Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: Q9NQX1
• Gene Symbols: PRDM5; PFM2
• Host Species: Mouse
• Immunogen: GST-tagged recombinant protein corresponding to human PRDM5 near the N-terminus.
• Purification Method: Protein G Purified
• Quantity: 200 μg
• Regulatory Status: RUO
• Research Discipline: Epigenetics and Nuclear Function
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_061169
• Target Species: Mouse
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Form: Purified
• Isotype: IgG2b κ

For Research Use Only