MilliporeSigma™ Mouse anti-Prestin, Clone: 3A2.2,

Catalog No.	Quantity
MABN746MI	100 μg

Catalog No. MABN746MI Supplier MilliporeSigma™ Supplier No. MABN746

Description

Mouse Monoclonal Antibody

Specifically detects Prestin clone: 3A2.2 in Mouse samples, and it is validated for Western Blotting

Prestin is a motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter that can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate to translocate anions toward or away from the extracellular plasma membrane surface. As a consequence, this translocation triggers conformational changes in Prestin that ultimately alter its surface area in the plane of the plasma membrane. Prestin acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space and in that process it helps to modulate the electro-physical signals necessary for hearing. Prestin is expressed in outer hair cells and localized to the cell membrane. Mutations in Prestin can lead to deafness.

Specifications

• Antigen: Prestin
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 3A2.2
• Formulation: Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
• Gene Accession No.: P58743
• Gene Symbols: SLC26A5; PRES
• Host Species: Mouse
• Immunogen: Linear peptide corresponding to human Prestin.
• Purification Method: Purified by Ion-Exchange Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Neuroscience
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_001161434
• Target Species: Mouse
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Form: Purified
• Isotype: IgM κ

For Research Use Only