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PRNP, Mouse, Clone: EM-20, Abnova™

Catalog No. 89112887 Shop All Abnova Corporation Products
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89-112-887 100 μg
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Catalog No. 89-112-887 Supplier Abnova Corporation Supplier No. MAB6472
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Description

Mouse monoclonal antibody raised against recombinant PRNP.

The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20kb upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq

Specifications

Antigen PRNP
Applications Western Blot
Classification Monoclonal
Clone EM-20
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against recombinant PRNP.
Dilution Western Blot (0.5 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In PBS, pH 7.4 (0.09% sodium azide)
Gene PRNP
Gene Alias ASCR/CD230/CJD/GSS/MGC26679/PRIP/PrP/PrP27-30/PrP33-35C/PrPc/prion
Gene Symbols PRNP
Host Species Mouse
Immunogen Recombinant protein corresponding to human PRNP.
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5621
Test Specificity This antibody recognizes human prion protein (PrP). Diglycosylated form of PrP has ∼40 KDa, monoglycosylated form ∼30 KDa, and nonglycosylated form ∼19-21 KDa. This antibody is suitable for discrimination between normal cellular prion protein (PrPc) and its conformationally changed form (PrPSc) prionprotein.
Target Species Human
Content And Storage Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG2a
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