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PRNP, Mouse, Clone: EM-20, Abnova™

Mouse monoclonal antibody raised against recombinant PRNP.

Supplier:  Abnova Corporation MAB6472

Catalog No. 89-112-887


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Description

Description

The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20kb upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq

Specifications

Specifications

PRNP
Monoclonal
Unconjugated
Western Blot (0.5 ug/mL) The optimal working dilution should be determined by the end user.
PRNP
PRNP
Recombinant protein corresponding to human PRNP.
RUO
5621
Human
Liquid
Western Blot
EM-20
Mouse monoclonal antibody raised against recombinant PRNP.
In PBS, pH 7.4 (0.09% sodium azide)
ASCR/CD230/CJD/GSS/MGC26679/PRIP/PrP/PrP27-30/PrP33-35C/PrPc/prion
Mouse
100 μg
Primary
This antibody recognizes human prion protein (PrP). Diglycosylated form of PrP has ∼40 KDa, monoglycosylated form ∼30 KDa, and nonglycosylated form ∼19-21 KDa. This antibody is suitable for discrimination between normal cellular prion protein (PrPc) and its conformationally changed form (PrPSc) prionprotein.
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.
IgG2a
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