PRNP, Mouse, Clone: EM-20, Abnova™

Mouse monoclonal antibody raised against recombinant PRNP.

Supplier:  Abnova Corporation MAB6472

Catalog No. 89-112-887

Description

The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20kb upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq

Specifications

• Antigen: PRNP
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: Western Blot (0.5 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: PRNP
• Gene Symbols: PRNP
• Immunogen: Recombinant protein corresponding to human PRNP.
• Regulatory Status: RUO
• Gene ID (Entrez): 5621
• Target Species: Human
• Form: Liquid

• Applications: Western Blot
• Clone: EM-20
• Description: Mouse monoclonal antibody raised against recombinant PRNP.
• Formulation: In PBS, pH 7.4 (0.09% sodium azide)
• Gene Alias: ASCR/CD230/CJD/GSS/MGC26679/PRIP/PrP/PrP27-30/PrP33-35C/PrPc/prion
• Host Species: Mouse
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: This antibody recognizes human prion protein (PrP). Diglycosylated form of PrP has ∼40 KDa, monoglycosylated form ∼30 KDa, and nonglycosylated form ∼19-21 KDa. This antibody is suitable for discrimination between normal cellular prion protein (PrPc) and its conformationally changed form (PrPSc) prionprotein.
• Content And Storage: Store at 4°C. Do not freeze.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG2a