PSEN1, Mouse, Clone: APS18, Abnova™

Catalog No.	Quantity
89-112-356	100 μg

Catalog No. 89-112-356 Supplier Abnova Corporation Supplier No. MAB5678

Description

Mouse monoclonal antibody raised against synthetic peptide of PSEN1.

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq]

Sequence: SKYNAESTERESQDTVAENDDG

Specifications

• Antigen: PSEN1
• Applications: ELISA, Immunohistochemistry, Western Blot
• Classification: Monoclonal
• Clone: APS18
• Conjugate: Unconjugated
• Description: presenilin 1
• Formulation: Lyophilized from PBS
• Gene: PSEN1
• Gene Alias: AD3, FAD, PS1, S182
• Gene Symbols: PSEN1
• Host Species: Mouse
• Immunogen: A synthetic peptide corresponding to amino acids 313-334 of human PSEN1.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5663
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C or -20°C on dry atmosphere. After reconstitution with water and glycerol (1:1), store at -20°C or -80°C. Aliquot to avoid repeated freezing and thawing.
• Form: Lyophilized
• Isotype: IgG1