PSEN2, Mouse, Clone: APS21, Abnova™

Catalog No.	Quantity
89-112-357	100 μg

Catalog No. 89-112-357 Supplier Abnova Corporation Supplier No. MAB5679

Description

Mouse monoclonal antibody raised against synthetic peptide of PSEN2.

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq]

Sequence: CQEGRQGPEDGENTA

Specifications

• Antigen: PSEN2
• Applications: ELISA, Immunofluorescence, Western Blot
• Classification: Monoclonal
• Clone: APS21
• Conjugate: Unconjugated
• Description: presenilin 2 (Alzheimer disease 4)
• Formulation: Lyophilized from PBS
• Gene: PSEN2
• Gene Alias: AD3L, AD4, PS2, STM2
• Gene Symbols: PSEN2
• Host Species: Mouse
• Immunogen: A synthetic peptide corresponding to amino acids 31-45 of human PSEN2.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5664
• Target Species: Human, Rat
• Content And Storage: Store at 4°C or -20°C on dry atmosphere. After reconstitution with water and glycerol (1:1), store at -20°C or -80°C. Aliquot to avoid repeated freezing and thawing.
• Form: Lyophilized
• Isotype: IgG1